Date: Thursday, December 1st, 2022
Time: 11:30 am - 1:00 pm EST

Plenary Lecture

Speaker: Dr. Mike Tobyn, Bristol Myers Squibb

Title of Talk: Small Particles, Big Data

Abstract: The bulk properties of powders (e.g. flow, compaction, sticking) have proved very resistant to prediction and modeling. When you have very limited amounts of powders and need to make decisions on how they will process that is awkward! Many potential modeling techniques assume that the particles are monosized spheres and behave uniformally. For the past 10 years we have been looking at better ways to analyse particles, getting more representative size and shape information, curating the data and then using machine learning to understand what the data. Now we can tell the story of 3000 batches of material, half a billion particles and 80GB of data and what we can infer from the models.

Time: 11:30 am

Short Talks

Speaker: Dr. Tina Skorjanc, University of Nova Gorica

Title of Talk: Cationic polymer thin films for electrochemical detection of bacteria

Abstract: Simple and affordable pathogen detection methods are much sought after as an alternative to complex biochemical, bacteriological and viral identification techniques. To address this need, we herein present a novel cationic covalent organic polymer synthesized through the Menshutkin reaction. The positive charges in this material are anticipated to serve as favorable docking sites for bacterial cells that generally possess a negatively-charged surface. Having fully characterized the synthesized material, we used a customized method of electrophoresis to deposit the material onto commercially available interdigitated Au electrodes. Thus-prepared polymer-coated electrodes were then employed in electrochemical impedance spectroscopy (EIS) sensing with E. coli as a model organism. The binding of E. coli cells to the sensing electrode increased the electron-transfer resistance, which was directly measured with EIS in the presence of [Fe(CN)6]3-/4- as a redox probe. Data showed a linear relationship between the bacterial concentration and the electron transfer resistance for various dilutions of E. coli ranging from 30 to 3·10^9 CFU/mL, and a low limit of detection of 2 CFU/mL.

Time: 12:10 pm

Speaker: Beth Galtry, University of Nottingham

Title of Talk: In situ X-ray diffraction of segmented flow crystallisation

Abstract: In situ X-ray diffraction of crystallisation enables the monitoring of crystal nucleation and growth, probing the polymorphic form and transformations during the crystallisation process. This presentation discusses the developments made to the KRAIC (kinetically regulated automated input crystalliser) series of crystallisers, a range of segmented flow crystallisation systems coupled with in situ X-ray diffraction in collaboration with Diamond Light Source, the UK’s synchrotron. Developed with beamline I11 (high resolution powder X-ray diffraction), the KRAIC-T, a temperature-cycling crystalliser, studies the temperature-dependent transitions of concomitant polymorphic systems during flow crystallisation or slurrying. Furthermore, the KRAIC-S, a cooling crystalliser with in situ single crystal X-ray diffraction, developed in collaboration with beamline I19 (small molecule single crystal X-ray diffraction), enables structural refinement of paracetamol single crystals in flow.

Time: 12:35 pm EST